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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HTRA2
All Species:
9.39
Human Site:
S74
Identified Species:
20.67
UniProt:
O43464
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O43464
NP_037379.1
458
48841
S74
E
P
R
A
C
L
T
S
G
T
P
G
P
R
A
Chimpanzee
Pan troglodytes
XP_508084
598
64926
P203
A
G
T
F
P
G
A
P
T
R
S
R
R
R
A
Rhesus Macaque
Macaca mulatta
XP_001110803
458
48732
S74
E
P
R
A
C
L
T
S
G
T
P
G
P
R
A
Dog
Lupus familis
XP_532992
199
21668
Cat
Felis silvestris
Mouse
Mus musculus
Q9JIY5
458
49330
S74
A
S
R
A
D
L
T
S
R
T
P
D
L
W
A
Rat
Rattus norvegicus
NP_001100069
458
49076
S74
A
S
R
A
N
L
T
S
G
T
P
D
L
W
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_420813
466
50374
C96
F
A
K
G
V
C
Q
C
K
L
S
V
Q
V
C
Frog
Xenopus laevis
NP_001088796
457
48812
A73
G
P
E
D
P
L
C
A
S
G
L
R
C
V
R
Zebra Danio
Brachydanio rerio
XP_001339411
294
31781
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VFJ3
422
45981
F71
L
V
R
F
F
V
P
F
S
L
G
A
V
V
S
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q3E6S8
459
49256
L75
D
A
R
T
R
V
S
L
A
I
P
E
S
V
R
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
38.9
99.1
41.7
N.A.
84.9
87.3
N.A.
N.A.
40.9
41
43.6
N.A.
42.3
N.A.
N.A.
N.A.
Protein Similarity:
100
52.5
99.1
42.5
N.A.
89.3
91.4
N.A.
N.A.
59.4
59.1
54.3
N.A.
59.3
N.A.
N.A.
N.A.
P-Site Identity:
100
13.3
100
0
N.A.
53.3
53.3
N.A.
N.A.
0
13.3
0
N.A.
6.6
N.A.
N.A.
N.A.
P-Site Similarity:
100
13.3
100
0
N.A.
53.3
53.3
N.A.
N.A.
6.6
20
0
N.A.
20
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
33.7
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
52
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
28
19
0
37
0
0
10
10
10
0
0
10
0
0
37
% A
% Cys:
0
0
0
0
19
10
10
10
0
0
0
0
10
0
10
% C
% Asp:
10
0
0
10
10
0
0
0
0
0
0
19
0
0
0
% D
% Glu:
19
0
10
0
0
0
0
0
0
0
0
10
0
0
0
% E
% Phe:
10
0
0
19
10
0
0
10
0
0
0
0
0
0
0
% F
% Gly:
10
10
0
10
0
10
0
0
28
10
10
19
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% I
% Lys:
0
0
10
0
0
0
0
0
10
0
0
0
0
0
0
% K
% Leu:
10
0
0
0
0
46
0
10
0
19
10
0
19
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
28
0
0
19
0
10
10
0
0
46
0
19
0
0
% P
% Gln:
0
0
0
0
0
0
10
0
0
0
0
0
10
0
0
% Q
% Arg:
0
0
55
0
10
0
0
0
10
10
0
19
10
28
19
% R
% Ser:
0
19
0
0
0
0
10
37
19
0
19
0
10
0
10
% S
% Thr:
0
0
10
10
0
0
37
0
10
37
0
0
0
0
0
% T
% Val:
0
10
0
0
10
19
0
0
0
0
0
10
10
37
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
19
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _